DELAYED ALLOGRAFT-REJECTION BY T-CELL RECEPTOR V-BETA-8.1 TRANSGENIC MICE PERIPHERALLY TOLERIZED TO MLS-1(A)

被引：9

作者：

BHANDOOLA, A ^{[1
]}

BASSIRI, H ^{[1
]}

MARKMANN, JF ^{[1
]}

YUI, K ^{[1
]}

HASHIMOTO, Y ^{[1
]}

GREENE, MI ^{[1
]}

机构：

[1] HOSP UNIV PENN,HARRISON DEPT SURG RES,PHILADELPHIA,PA 19104

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1994年 / 24卷 / 07期

关键词：

PERIPHERAL TOLERANCE; SUPERANTIGEN; T CELL; ALLOGRAFT REJECTION;

D O I：

10.1002/eji.1830240739

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

One commonly studied model system for peripheral tolerance is the antigen-specific unresponsiveness of T cells from mice previously inoculated with superantigens such as Mls-1(a). In this study, we used a TcR V beta 8.1 transgenic mouse model to investigate whether mice peripherally tolerized to Mls-1(a) exhibit delayed skin allograft rejection.We report dramatic prolongation of skin allograft survival in V beta 8.1 transgenic but not in non-transgenic mice tolerized to Mls-1(a). Peripherally induced unresponsiveness to Mls-1(a) can, therefore, be considered true tolerance.

引用

页码：1710 / 1713

页数：4

共 14 条

[1] PROLIFERATIVE T-CELL ANERGY TO MLS-1A DOES NOT CORRELATE WITH INVIVO TOLERANCE [J].

BANDEIRA, A ;

MENGEL, J ;

BURLENDEFRANOUX, O ;

COUTINHO, A .

INTERNATIONAL IMMUNOLOGY, 1991, 3 (09) :923-931

[2]

BHANDOOLA A, 1993, J IMMUNOL, V151, P2355

[3]

BILLINGHAM RE, 1951, J EXP BIOL, V28, P385

[4] SELECTIVE ANERGY OF V-BETA-8+,CD4+ T-CELLS IN STAPHYLOCOCCUS ENTEROTOXIN B-PRIMED MICE [J].

KAWABE, Y ;

OCHI, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (04) :1065-1070

[5]

KOLLER BH, 1990, SCIENCE, V248, P1227, DOI 10.1126/science.2112266

[6] THE FUNCTIONAL AND HISTOLOGICAL BASIS FOR GRAFT-VERSUS-HOST-INDUCED IMMUNOSUPPRESSION [J].

LAPP, WS ;

GHAYUR, T ;

MENDES, M ;

SEDDIK, M ;

SEEMAYER, TA .

IMMUNOLOGICAL REVIEWS, 1985, 88 :107-133

[7] THE JAM TEST - A SIMPLE ASSAY FOR DNA FRAGMENTATION AND CELL-DEATH [J].

MATZINGER, P .

JOURNAL OF IMMUNOLOGICAL METHODS, 1991, 145 (1-2) :185-192

[8] CLONAL ANERGY INDUCED IN MATURE V-BETA-6+ LYMPHOCYTES-T ON IMMUNIZING MLS-1B MICE WITH MLS-1A EXPRESSING CELLS [J].

RAMMENSEE, HG ;

KROSCHEWSKI, R ;

FRANGOULIS, B .

NATURE, 1989, 339 (6225) :541-544

[9] INVIVO INDUCTION OF ANERGY IN PERIPHERAL V-BETA-8+ T-CELLS BY STAPHYLOCOCCAL ENTEROTOXIN-B [J].

RELLAHAN, BL ;

JONES, LA ;

KRUISBEEK, AM ;

FRY, AM ;

MATIS, LA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (04) :1091-1100

[10] CELLULAR BASIS OF SKIN ALLOGRAFT-REJECTION - AN INVIVO MODEL OF IMMUNE-MEDIATED TISSUE DESTRUCTION [J].

ROSENBERG, AS ;

SINGER, A .

ANNUAL REVIEW OF IMMUNOLOGY, 1992, 10 :333-358

← 1 2 →