BEHAVIORAL-RESPONSE TO SKF-38393 AND QUINPIROLE FOLLOWING CHRONIC ANTIDEPRESSANT TREATMENT

被引：9

作者：

ALLISON, K ^{[1
]}

IVANOVA, S ^{[1
]}

GREENSHAW, AJ ^{[1
]}

机构：

[1] UNIV ALBERTA,DEPT PSYCHIAT,NEUROCHEM RES UNIT,EDMONTON,AB T6G 2B7,CANADA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 277卷 / 2-3期

关键词：

ANTIDEPRESSANT; DOPAMINE RECEPTOR; QUINPIROLE; SKF; 38393; MOTOR ACTIVITY;

D O I：

10.1016/0014-2999(95)00059-T

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of chronic administration of antidepressant drugs (21-22 days s.c. via osmotic mini-pumps) on the behavioural responses of male Sprague-Dawley rats to (-)-quinpirole hydrochloride (0.05 mg kg(-1) s.c., 5 min) and (+/-)-SKF 38393 hydrochloride (10 mg kg(-1) s.c., 5 min) were investigated. Desipramine hydrochloride (10 mg kg(-1) per day), phenelzine sulphate (10 mg kg(-1) per day) and clorgyline hydrochloride (1 mg kg(-1) per day) attenuated the suppression of locomotor activity induced by quinpirole, a dopamine D-2-like receptor agonist, while clomipramine hydrochloride (10 mg kg(-1) per day) was without effect. Yawning elicited by quinpirole was absent in phenelzine- and clorgyline-treated rats, but unaffected in rats treated chronically with desipramine and clomipramine. SKF 38393, a dopamine D-2-like receptor agonist, significantly increased locomotor activity and time spent grooming in control animals. There were no significant effects of antidepressants on the behavioural responses to SKF 38393.

引用

页码：139 / 144

页数：6

共 40 条

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