CYTOLOGIC ATYPIA ASSOCIATED WITH MICROGLANDULAR HYPERPLASIA

被引：28

作者：

VALENTE, PT

SCHANTZ, HD

SCHULTZ, M

机构：

[1] Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas

来源：

DIAGNOSTIC CYTOPATHOLOGY | 1994年 / 10卷 / 04期

关键词：

CERVICOVAGINAL SMEARS; GLANDULAR ATYPIA; ORAL CONTRACEPTIVES;

D O I：

10.1002/dc.2840100407

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Although it has long been known that microglandular hyperplasia (MGH) may be associated with cytologic atypia in cervical smears, the cytomorphology of MGH has not been described in great detail. To clarify its cytomorphology, Pap smears obtained from biopsy proven cases of MGH over a 3-yr period were reviewed. Of 122 smears containing endocervical cells, 34 (28%) showed striking glandular abnormalities. In two cases, adenocarcinoma and adenocarcinoma in situ were falsely suggested and a high grade squamous intraepithelial lesion (HGSIL-CIN III) was not confirmed in a conization specimen which showed only low grade SIL and MGH. Review of six cytologic diagnoses of HGSIL (CIN III) unconfirmed on biopsy suggested overcalls related to MGH related atypia in five. Cytologic features of MGH, therefore, may occasionally result in erroneous interpretations of HGSIL as well as glandular neoplasia. Although these changes may be striking, comparison with glandular atypia not associated with MGH shows that they are not entirely specific. (C) 1994 Wiley-Liss, Inc.

引用

页码：326 / 331

页数：6

共 18 条

[1]

Kline TS, Holland M, Wemple D, Atypical cytology with contraceptive hormone medication, Am J Clin Pathol, 53, pp. 215-222, (1970)

[2]

Yahr LJ, Lee KR, Cytologic findings in microglandular hyperplasia of the cervix, Diagn Cytopathol, 7, pp. 248-251, (1991)

[3]

Leslie KO, Silverberg SG, Microglandular hyperplasia of the cervix: Unusual clinical and pathologic presentations and their differential diagnosis, Progress in surgical pathology, pp. 95-114, (1983)

[4]

Bibbo M, Keebler CM, Wied GL, The cytologic diagnosis of tissue repair in the female genital tract, Acta Cytol, 15, pp. 3-137, (1971)

[5]

Govan ADT, Black WP, Sharp JL, Aberrant glandular polypi of the uterine cervix associated with contraceptive pills: Pathology and pathogenesis, J Clin Pathol, 22, pp. 84-89, (1969)

[6]

Kyriakos M, Kempson RL, Konikov NF, A clinical and pathologic study of endocervical lesions associated with oral contraceptives, Cancer, 22, pp. 99-110, (1968)

[7]

Nichols TM, Fidler HK, Microglandular hyperplasia in cervical cone biopsies taken for suspicious and positive cytology, Am J Clin Pathol, 56, pp. 424-429, (1971)

[8]

Taylor HB, Irey NS, Norris HJ, Atypical endocervical hyperplasia in women taking oral contraceptives, JAMA, 207, pp. 185-187, (1967)

[9]

Chumas JC, Nelson B, Mann WJ, Chelas E, Kaplan CG, Microglandular hyperplasia of the uterine cervix, Obstet Gynecol, 66, pp. 406-409, (1985)

[10]

Young RH, Scully RE, Atypical forms of microglandular hyperplasia simulating carcinoma. A report of five cases and a review of the literature, Am J Surg Pathol, 13, pp. 50-56, (1989)

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