DIETARY-CHOLESTEROL, FAT, AND LUNG-CANCER INCIDENCE AMONG OLDER WOMEN - THE IOWA WOMENS HEALTH STUDY (UNITED-STATES)

被引：36

作者：

WU, Y ^{[1
]}

ZHENG, W ^{[1
]}

SELLERS, TA ^{[1
]}

KUSHI, LH ^{[1
]}

BOSTICK, RM ^{[1
]}

POTTER, JD ^{[1
]}

机构：

[1] UNIV MINNESOTA,SCH PUBL HLTH,DIV EPIDEMIOL,1300 S 2ND ST,SUITE 300,MINNEAPOLIS,MN 55454

来源：

CANCER CAUSES & CONTROL | 1994年 / 5卷 / 05期

关键词：

CHOLESTEROL; COHORT STUDY; DIET; FAT; LUNG CANCER; NUTRITION; UNITED-STATES;

D O I：

10.1007/BF01694752

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To test the hypothesis that a high intake of dietary cholesterol and fat is associated with elevated risks of lung cancer, we analyzed data from a population-based, prospective, cohort study conducted among 41,837 post-menopausal Iowa (United States) women who completed, in 1986, a comprehensive mailed questionnaire including information on usual intake of 127 food items. All cohort members were followed for cancer incidence through the statewide cancer registry. By 1991, after six years of follow-up, 272 incident lung-cancer cases were identified. After controlling for total energy intake and other confounding factors, dietary cholesterol, total fat, and animal fat were unrelated to lung cancer risk. Intake in the upper three quartiles of plant-derived fat, however, was related to a 30 to 40 percent lower incidence of lung cancer, compared with those in the lowest quartile, with more pronounced reduction in risk observed among smokers (relative risk = 0.6, 95 percent confidence interval = 0.4-0.9). This prospective cohort study suggests that high intake of fat of plant origin may be associated with reduced risk of lung cancer, while dietary cholesterol and animal fat intake is unrelated to the etiology of this malignancy in postmenopausal women.

引用

页码：395 / 400

页数：6

共 27 条

[1]

Muir C., Waterhouse J., Mack T., Powell J., Whelan S., Cancer Incidence in Five Continents Vol 5, (1987)

[2]

Kabat G.C., Recent developments in the epidemiology of lung cancer, Semin Surg Oncol, 9, 2, pp. 73-9, (1993)

[3]

Jain M., Burch J.D., Howe G.R., Risch H.A., Miller A.B., Dietary factors and risk of lung cancer: results from a case-control study, Toronto, 1981–1985, Int J Cancer, 45, pp. 287-93, (1990)

[4]

Byers T.E., Graham S., Haughey B.P., Marshall J.R., Swanson M.K., Diet and lung cancer risk: findings from the Western New York Study, Am J Epidemiol, 125, pp. 351-63, (1987)

[5]

Hinds M.W., Kolonel L.N., Hankin J.H., Lee J., Dietary cholesterol and lung cancer risk in a multiethnic population in Hawaii, Int J Cancer, 32, pp. 727-32, (1983)

[6]

Goodman M.T., Kolonel L.N., Yoshizawa C.N., Hankin J.H., The effect of dietary cholesterol and fat on the risk of lung cancer in Hawaii, Am J Epidemiol, 128, pp. 1241-55, (1988)

[7]

Alvanja M.C.R., Brown C.C., Swanson C., Brownson R.C., Saturated fat intake and lung cancer risk among nonsmoking women in Missouri, JNCI Journal of the National Cancer Institute, 85, pp. 1906-16, (1993)

[8]

Shekelle R.B., Rossof A.H., Stamler J., Dietary cholesterol and incidence of lung cancer: the Western Electric Study, Am J Epidemiol, 134, pp. 480-4, (1991)

[9]

Knekt P., Seppanen R., Jarvinen R., Et al., Dietary cholesterol, fatty acids, and the risk of lung cancer among men, Nutr Cancer, 16, pp. 267-75, (1991)

[10]

Heilbrun L.K., Nomura A.M., Stemmermann G.N., Dietary cholesterol and lung cancer risk among Japanese men in Hawaii, Am J Clin Nutr, 39, pp. 375-9, (1984)

← 1 2 3 →