NOVEL INHIBITORS OF CHOLESTERYL ESTER TRANSFER PROTEIN

被引：14

作者：

CHACKALAMANNIL, S

XIA, Y

WANG, YG

TSAI, HG

CZARNIECKI, M

WANG, S

CLEMMONS, A

AHN, HS

BOYKOW, G

机构：

[1] Schering-Plough Research Institute, Kenilworth, NJ 07033

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 17期

关键词：

D O I：

10.1016/0960-894X(95)00342-Q

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and CETP inhibitory activity of a series of compounds related to wiedendiols (1a,1b) are reported. It is proposed that a two point pharmacophore consisting of a catechol group and a large hydrophobic anchor is necessary for activity.

引用

页码：2005 / 2010

页数：6

共 13 条

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