USE OF PLASMA PHARMACOKINETICS TO PREDICT AND PREVENT METHOTREXATE TOXICITY

被引：383

作者：

STOLLER, RG

HANDE, KR

JACOBS, SA

ROSENBERG, SA

CHABNER, BA

机构：

[1] NIH, BETHESDA, MD 20014 USA

[2] NCI, CLIN PHARMACOL BRANCH, BETHESDA, MD 20014 USA

[3] NCI, SURG BRANCH, BETHESDA, MD 20014 USA

[4] NCI, MED BRANCH, BETHESDA, MD 20014 USA

来源：

关键词：

D O I：

10.1056/NEJM197709222971203

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：630 / 634

页数：5

共 17 条

[1] BERTINO J R, 1964, Methods Med Res, V10, P297
[2] THRESHOLD METHOTREXATE CONCENTRATION FOR IN-VIVO INHIBITION OF DNA-SYNTHESIS IN NORMAL AND TUMOROUS TARGET TISSUES
CHABNER, BA
YOUNG, RC
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1973, 52 (08) : 1804 - 1811
[3] ENZYMATIC CLEAVAGE OF METHOTREXATE PROVIDES A METHOD FOR PREVENTION OF DRUG TOXICITY
CHABNER, BA
BERTINO, JR
JOHNS, DG
[J]. NATURE, 1972, 239 (5372) : 395 - &
[4] DJERASSI I, 1967, CANCER, V20, P233, DOI 10.1002/1097-0142(1967)20:2<233::AID-CNCR2820200209>3.0.CO
[5] 2-8
[6] DJERASSI I, 1977, CANCER TREAT REP, V61, P751
[7] DJERASSI I, 1972, CANCER, V30, P22, DOI 10.1002/1097-0142(197207)30:1<22::AID-CNCR2820300105>3.0.CO
[8] 2-B
[9] 7-HYDROXYMETHOTREXATE AS A URINARY METABOLITE IN HUMAN SUBJECTS AND RHESUS-MONKEYS RECEIVING HIGH DOSE METHOTREXATE
JACOBS, SA
STOLLER, RG
CHABNER, BA
JOHNS, DG
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1976, 57 (02) : 534 - 538
[10] JAFFE N, 1972, CANCER-AM CANCER SOC, V30, P1627, DOI 10.1002/1097-0142(197212)30:6<1627::AID-CNCR2820300631>3.0.CO