PARTITIONING OF DIOXIN AND DIBENZOFURAN CONGENERS BETWEEN PLASMA AND CELL-FRACTIONS OF BLOOD FROM 10 ADULT MALE-PATIENTS

被引：5

作者：

SCHECTER, A

RYAN, JJ

CONSTABLE, JD

机构：

[1] HLTH & WELF CANADA,OTTAWA K1A 0L2,ONTARIO,CANADA

[2] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,BOSTON,MA 02114

来源：

CHEMOSPHERE | 1992年 / 25卷 / 12期

关键词：

D O I：

10.1016/0045-6535(92)90039-T

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

We previously characterized levels of dioxin and dibenzofuran congeners in adipose tissue and plasma fraction of blood collected from 20 adult males, using paired specimens. It has been found that the 2,3,7,8-TCDD level reported on a lipid basts was similar, although not identical, in plasma lipid and in adipose tissue lipid from the same patients, however, higher levels of the more chlorinated dioxins and dibenzofurans existed in plasma lipid as compared to adipose tissue lipid. This study reports measurements from ten individuals' blood cell fraction and compares this to the plasma fraction and to adipose tissue lipid. In all cases where readily detectable amounts of PCDD/Fs were found, a minimum of 85% was in the plasma fraction and less than 15% in the cellular component. Congeners varied in percentage for each component.

引用

收藏

页码：2017 / 2022

页数：6

相关论文

共 13 条

[1] LEVELS OF PCDDS AND PCDFS IN ADIPOSE-TISSUE OF OCCUPATIONALLY EXPOSED WORKERS [J].

BECK, H ;

ECKART, K ;

MATHAR, W ;

WITTKOWSKI, R .

CHEMOSPHERE, 1989, 18 (1-6) :507-516

[2] DIOXINS AND DIBENZOFURANS IN BLOOD AND ADIPOSE-TISSUE OF AGENT ORANGE - EXPOSED VIETNAM VETERANS AND MATCHED CONTROLS [J].

KAHN, PC ;

GOCHFELD, M ;

NYGREN, M ;

HANSSON, M ;

RAPPE, C ;

VELEZ, H ;

GHENTGUENTHER, T ;

WILSON, WP .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1988, 259 (11) :1661-1667

[3] CORRELATION BETWEEN SERUM AND ADIPOSE-TISSUE LEVELS OF 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN IN 50 PERSONS FROM MISSOURI [J].

PATTERSON, DG ;

NEEDHAM, LL ;

PIRKLE, JL ;

ROBERTS, DW ;

BAGBY, J ;

GARRETT, WA ;

ANDREWS, JS ;

FALK, H ;

BERNERT, JT ;

SAMPSON, EJ ;

HOUK, VN .

ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 1988, 17 (02) :139-143

[4] A METHOD PERFORMANCE EVALUATION AND LESSONS LEARNED AFTER ANALYZING MORE THAN 5,000 HUMAN ADIPOSE-TISSUE, SERUM, AND BREAST-MILK SAMPLES FOR POLYCHLORINATED DIBENZO-PARA-DIOXINS (PCDDS) AND DIBENZOFURANS (PCDFS) [J].

PATTERSON, DG ;

TURNER, WE ;

ISAACS, SG ;

ALEXANDER, LR .

CHEMOSPHERE, 1990, 20 (7-9) :829-836

[5] HIGH-RESOLUTION GAS-CHROMATOGRAPHIC HIGH-RESOLUTION MASS-SPECTROMETRIC ANALYSIS OF HUMAN-SERUM ON A WHOLE-WEIGHT AND LIPID BASIS FOR 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN [J].

PATTERSON, DG ;

HAMPTON, L ;

LAPEZA, CR ;

BELSER, WT ;

GREEN, V ;

ALEXANDER, L ;

NEEDHAM, LL .

ANALYTICAL CHEMISTRY, 1987, 59 (15) :2000-2005

[6] PARTITIONING OF INVIVO BOUND PCDDS/PCDFS AMONG VARIOUS COMPARTMENTS IN WHOLE-BLOOD [J].

PATTERSON, DG ;

FURST, P ;

HENDERSON, LO ;

ISAACS, SG ;

ALEXANDER, LR ;

TURNER, WE ;

NEEDHAM, LL ;

HANNON, H .

CHEMOSPHERE, 1989, 19 (1-6) :135-142

[7] HIGH-RESOLUTION GAS CHROMATOGRAPHIC/HIGH-RESOLUTION MASS-SPECTROMETRIC ANALYSIS OF HUMAN ADIPOSE-TISSUE FOR 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN [J].

PATTERSON, DG ;

HOLLER, JS ;

LAPEZA, CR ;

ALEXANDER, LR ;

GROCE, DF ;

OCONNOR, RC ;

SMITH, SJ ;

LIDDLE, JA ;

NEEDHAM, LL .

ANALYTICAL CHEMISTRY, 1986, 58 (04) :705-713

[8] DIOXINS, DIBENZOFURANS AND SELECTED CHLORINATED ORGANIC-COMPOUNDS IN HUMAN-MILK AND BLOOD FROM CAMBODIA, GERMANY, THAILAND, THE USA, THE USSR, AND VIETNAM [J].

SCHECTER, A ;

FURST, P ;

FURST, C ;

PAPKE, O ;

BALL, M ;

DAI, LC ;

QUYNH, HT ;

PHOUNG, NTN ;

BEIM, A ;

VLASOV, B ;

CHONGCHET, V ;

CONSTABLE, JD ;

CHARLES, K .

CHEMOSPHERE, 1991, 23 (11-12) :1903-1912

[9] BLOOD AND ADIPOSE-TISSUE LEVELS OF PCDDS PCDFS OVER 3 YEARS IN A PATIENT AFTER EXPOSURE TO POLYCHLORINATED DIOXINS AND DIBENZOFURANS [J].

SCHECTER, A ;

RYAN, JJ .

CHEMOSPHERE, 1989, 18 (1-6) :635-642

[10] PARTITIONING OF 2,3,7,8-CHLORINATED DIBENZO-PARA-DIOXINS AND DIBENZOFURANS BETWEEN ADIPOSE-TISSUE AND PLASMA-LIPID OF 20 MASSACHUSETTS VIETNAM VETERANS [J].

SCHECTER, A ;

RYAN, JJ ;

CONSTABLE, JD ;

BAUGHMAN, R ;

BANGERT, J ;

FURST, P ;

WILMERS, K ;

OATES, RP .

CHEMOSPHERE, 1990, 20 (7-9) :951-958