A COAT SUBUNIT OF GOLGI-DERIVED NON-CLATHRIN-COATED VESICLES WITH HOMOLOGY TO THE CLATHRIN-COATED VESICLE COAT PROTEIN BETA-ADAPTIN

被引：312

作者：

SERAFINI, T

STENBECK, G

BRECHT, A

LOTTSPEICH, F

ORCI, L

ROTHMAN, JE

WIELAND, FT

机构：

[1] PRINCETON UNIV,DEPT MOLEC BIOL,PRINCETON,NJ 08544

[2] UNIV HEIDELBERG,INST BIOCHEM 1,W-6900 HEIDELBERG,GERMANY

[3] MAX PLANCK INST BIOCHEM,GENZENTRUM,W-8033 MARTINSRIED,GERMANY

[4] UNIV GENEVA,DEPT MORPHOL,CH-1211 GENEVA 4,SWITZERLAND

来源：

NATURE | 1991年 / 349卷 / 6306期

关键词：

D O I：

10.1038/349215a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Four high-molecular-weight proteins form the main subunits of the coat of Golgi-derived (non-clathrin) coated vesicles. One of these coat proteins, beta-COP, is identical to a Golgi-associated protein of relative mass 110,000 (110K) that shares homology with the adaptin proteins of clathrin-coated vesicles. This connection, and the comparable molecular weights of the coat proteins of Golgi-derived and clathrin-coated vesicles, indicates that they may be structurally related. The identification of beta-COP as the 110K protein explains the blocking of secretion by the drug brefeldin A.

引用

页码：214 / 220

页数：7

共 51 条

[1] AHLE S, 1989, J BIOL CHEM, V264, P20089
[2] STRUCTURAL RELATIONSHIPS BETWEEN CLATHRIN ASSEMBLY PROTEINS FROM THE GOLGI AND THE PLASMA-MEMBRANE
AHLE, S
MANN, A
EICHELSBACHER, U
UNGEWICKELL, E
[J]. EMBO JOURNAL, 1988, 7 (04) : 919 - 929
[3] A MICROTUBULE-BINDING PROTEIN ASSOCIATED WITH MEMBRANES OF THE GOLGI-APPARATUS
ALLAN, VJ
KREIS, TE
[J]. JOURNAL OF CELL BIOLOGY, 1986, 103 (06) : 2229 - 2239
[4] RECONSTITUTION OF THE TRANSPORT OF PROTEIN BETWEEN SUCCESSIVE COMPARTMENTS OF THE GOLGI MEASURED BY THE COUPLED INCORPORATION OF N-ACETYLGLUCOSAMINE
BALCH, WE
DUNPHY, WG
BRAELL, WA
ROTHMAN, JE
[J]. CELL, 1984, 39 (02) : 405 - 416
[5] CHARACTERIZATION OF PROTEIN-TRANSPORT BETWEEN SUCCESSIVE COMPARTMENTS OF THE GOLGI-APPARATUS - ASYMMETRIC PROPERTIES OF DONOR AND ACCEPTOR ACTIVITIES IN A CELL-FREE SYSTEM
BALCH, WE
ROTHMAN, JE
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1985, 240 (01) : 413 - 425
[6] SEQUENTIAL INTERMEDIATES IN THE PATHWAY OF INTERCOMPARTMENTAL TRANSPORT IN A CELL-FREE SYSTEM
BALCH, WE
GLICK, BS
ROTHMAN, JE
[J]. CELL, 1984, 39 (03) : 525 - 536
[7] BALCH WE, 1983, METHOD ENZYMOL, V98, P37
[8] ASSAY OF PROTEINS IN PRESENCE OF INTERFERING MATERIALS
BENSADOUN, A
WEINSTEIN, D
[J]. ANALYTICAL BIOCHEMISTRY, 1976, 70 (01) : 241 - 250
[9] PURIFICATION OF AN N-ETHYLMALEIMIDE-SENSITIVE PROTEIN CATALYZING VESICULAR TRANSPORT
BLOCK, MR
GLICK, BS
WILCOX, CA
WIELAND, FT
ROTHMAN, JE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (21) : 7852 - 7856
[10] BREFELDIN-A REDISTRIBUTES RESIDENT AND ITINERANT GOLGI PROTEINS TO THE ENDOPLASMIC-RETICULUM
DOMS, RW
RUSS, G
YEWDELL, JW
[J]. JOURNAL OF CELL BIOLOGY, 1989, 109 (01) : 61 - 72

← 1 2 3 4 5 6 →