IMMUNOLOCALIZATION OF 2 CYTOCHROME-P450 ISOZYMES IN RAT NASAL CHEMOSENSORY TISSUE

被引：87

作者：

CHEN, Y

GETCHELL, ML

DING, XX

GETCHELL, TV

机构：

[1] UNIV KENTUCKY,COLL MED,DIV OTOLARYNGOL HEAD & NECK SURG,LEXINGTON,KY 40536

[2] UNIV KENTUCKY,COLL MED,SANDERS BROWN CTR AGING,LEXINGTON,KY 40536

[3] UNIV KENTUCKY,COLL MED,DEPT PHYSIOL & BIOPHYS,LEXINGTON,KY 40536

[4] UNIV MICHIGAN,SCH MED,DEPT BIOL CHEM,ANN ARBOR,MI 48109

来源：

NEUROREPORT | 1992年 / 3卷 / 09期

关键词：

PHASE-I BIOTRANSFORMATION ENZYMES; XENOBIOTIC METABOLISM; OLFACTORY MUCOSA; SEPTAL ORGAN OF MASERA; VOMERONASAL ORGAN; PERIRECEPTOR EVENTS; NMA; NMB;

D O I：

10.1097/00001756-199209000-00007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE NMa and NMb isoforms of cytochrome P450 enzymes are expressed in three nasal chemosensory organs: the olfactory, septal and vomeronasal mucosae. The NMa isoform is widely distributed throughout the nasal mucosa whereas the NMb isoform is present primarily in the chemosensory mucosae. The localization of cytochromes P450 demonstrates that sustentacular cells in the olfactory and septal epithelia, the mucus of the vomeronasal organ and the acinar cells of glands in the lamina propria of all three chemosensory systems engage in xenobiotic metabolism and participate in odorant/pheromone clearance, a perireceptor process associated with chemosensory transduction.

引用

页码：749 / 752

页数：4

共 23 条

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