NOR-MEFLOQUINE - STEREOSPECIFIC SYNTHESIS AND BIOLOGICAL PROPERTIES

被引：4

作者：

ADAM, S

机构：

[1] Pharmaceutical Research Department F. Hoffman-La Roche AG.

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(00)80654-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nor-mefloquine, the pyrrolidinyl analog 1 related to mefloquine has been synthesised in a stereospecific way resting on the E geometry of the key-step olefin 4 obtained via the Heck's palladium-catalysed vinylic substitution reaction. Against P. berghei in vivo (mice). 1 was as active as mefloquine.

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页码：53 / 58

页数：6

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