POTENT ANTIMALARIAL ACTIVITY OF THE ALKALOID NITIDINE, ISOLATED FROM A KENYAN HERBAL REMEDY

被引：80

作者：

GAKUNJU, DMN

MBERU, EK

DOSSAJI, SF

GRAY, AI

WAIGH, RD

WATERMAN, PG

WATKINS, WM

机构：

[1] UNIV STRATHCLYDE,DEPT PHARMACEUT SCI,GLASGOW,LANARK,SCOTLAND

[2] MINIST HLTH,NAIROBI,KENYA

[3] WELLCOME TRUST RES LABS,NAIROBI,KENYA

[4] NATL MUSEUMS KENYA,NAIROBI,KENYA

[5] KENYA GOVT MED RES CTR,NAIROBI,KENYA

[6] UNIV LIVERPOOL,DEPT PHARMACOL & THERAPEUT,LIVERPOOL,MERSEYSIDE,ENGLAND

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 12期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/AAC.39.12.2606

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Bioassay-guided fractionation of extracts of Toddalia asiatica, a plant used by the Pokot tribe of Kenya to treat fevers, has yielded the alkaloid nitidine as the major antimalarial component. Fractions containing nitidine have in vitro 50% inhibitory concentrations against Plasmodium falciparum in the range of 9 to 108 ng/ml for a range of chloroquine-susceptible and -resistant strains. The results show a lack of cross-resistance between chloroquine and nitidine.

引用

页码：2606 / 2609

页数：4

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