EFFECT OF FAST VS SLOW INTRALIPID INFUSION ON GAS-EXCHANGE, PULMONARY HEMODYNAMICS, AND PROSTAGLANDIN METABOLISM

被引：38

作者：

MATHRU, M ^{[1
]}

DRIES, DJ ^{[1
]}

ZECCA, A ^{[1
]}

FAREED, J ^{[1
]}

ROONEY, MW ^{[1
]}

RAO, TLK ^{[1
]}

机构：

[1] LOYOLA UNIV,MED CTR,DEPT SURG,MAYWOOD,IL 60153

来源：

CHEST | 1991年 / 99卷 / 02期

关键词：

D O I：

10.1378/chest.99.2.426

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Intralipid (20 percent, 500 ml) was infused fast (5 h) or slow (10 h) randomly in patients with lung injury to relate changes in plasma prostaglandin (PG) concentrations to gas exchange and pulmonary hemodynamics. Data were collected at baseline, midpoint of infusion, and 2 h following infusion. Vasodilator and vasoconstrictor PG metabolites, 6-keto-PGF1-alpha, and thromboxane B2, respectively, were measured in radial arterial blood samples. Slow Intralipid infusion increased shunt fraction (Q(S)/Q(T)) without changing mean pulmonary artery pressure (MPAP), whereas fast Intralipid infusion increased MPAP without changing Q(S)/Q(T). Prostaglandin levels did not change significantly during either infusion. However, in both groups when the PG substrate was removed, hemodynamic and metabolite values decreased in parallel. In conclusion, we were unable to demonstrate a cause and effect relationship between plasma levels of 6-keto-PGF1-alpha and thromboxane B2 and the observed pulmonary hemodynamic response to slow or fast Intralipid infusion.

引用

页码：426 / 429

页数：4

共 14 条

[1] NUTRITION FOR THE PATIENT WITH RESPIRATORY-FAILURE - GLUCOSE VS FAT [J].