WHICH 3-RIBOFURANOSYL-SUBSTITUTED PURINE 5'-PHOSPHATES UNDERGO TEMPLATE-DIRECTED OLIGOMERIZATION

被引：5

作者：

HILL, AR

KUMAR, S

PATIL, VD

LEONARD, NJ

ORGEL, LE

机构：

[1] SALK INST BIOL STUDIES,POB 85800,SAN DIEGO,CA 92186

[2] UNIV ILLINOIS,SCH CHEM SCI,URBANA,IL 61801

来源：

JOURNAL OF MOLECULAR EVOLUTION | 1991年 / 32卷 / 06期

关键词：

3-ISOISOGUANOSINE 5'-PHOSPHATE; 3-ISOXANTHOSINE 5'-PHOSPHATE; TEMPLATE-DIRECTED SYNTHESIS; PHOSPHOROIMIDAZOLIDES;

D O I：

10.1007/BF02102646

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have studied the oligomerization reactions of the 2-methylimidazolide derivatives of 3-isoisoguanosine 5'-phosphate (2) and 3-isoxanthosine 5'-phosphate (5) in the presence of a variety of homopolynucleotide templates. In no case did we observe a substantial template-facilitated production of long oligomers. Polyuridylic acid directed the synthesis of low molecular-weight products from both monomers. Polycytidylic acid, polyadenylic acid, polyinosinic acid, and polyguanylic acid were ineffective as templates in the systems that we investigated.

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页码：447 / 453

页数：7

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