HYDROGEN-PEROXIDE MODULATION OF THE RESPIRATORY BURST OF HUMAN NEUTROPHILS

被引：16

作者：

WINN, JS ^{[1
]}

GUILLE, J ^{[1
]}

GEBICKI, JM ^{[1
]}

DAY, RO ^{[1
]}

机构：

[1] ST VINCENTS HOSP, DEPT CLIN PHARMACOL & TOXICOL, DARLINGHURST, NSW 2010, AUSTRALIA

来源：

BIOCHEMICAL PHARMACOLOGY | 1991年 / 41卷 / 01期

关键词：

D O I：

10.1016/0006-2952(91)90007-R

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Addition of micromolar concentrations of hydrogen peroxide (H2O2) to human neutrophils resulted in a dose-dependent luminol-enhanced chemiluminescent response. Pretreatment of neutrophils with micromolar concentrations of H2O2 altered their response to the surface acting stimulants serum-treated zymosan (STZ) and formyl-methionyl-leucyl-phenylalanine (fMLP), but not to the intracellular stimulant phorbol myristate acetate (PMA). The alterations were partially reversible by catalase, but exacerbated by superoxide dismutase. These results suggest a modulatory role for H2O2 in the respiratory burst of neutrophils.

引用

页码：31 / 36

页数：6

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