THE EFFECT OF RESTRAINT STRESS ON THE KINETICS, MAGNITUDE, AND ISOTYPE OF THE HUMORAL IMMUNE-RESPONSE TO INFLUENZA-VIRUS INFECTION

被引:43
作者
FENG, NG
PAGNIANO, R
TOVAR, CA
BONNEAU, RH
GLASER, R
SHERIDAN, JF
机构
[1] OHIO STATE UNIV,COLL MED,DEPT ORAL BIOL,COLUMBUS,OH 43210
[2] OHIO STATE UNIV,COLL DENT,COLUMBUS,OH 43210
关键词
D O I
10.1016/0889-1591(91)90032-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The stress of physical restraint has been shown to modulate the cellular immune response during a viral infection. We have studied the effects of stress on the humoral immune response during infection by influenza virus. Restraint stress altered the kinetics of the antibody response; seroconversion in the IgG and IgA isotypes was delayed in virus-infected C57BL 6 mice subjected to repeated cycles of physical restraint. However, the magnitude and isotype of the mature antibody response were unaffected during the plateau phase; no significant differences were observed between restrained/infected and nonrestrained/infected mice. Thus, the time during infection at which the antibody response was measured was a significant variable in the study of stress-induced alterations of the host's response to a replicating viral antigen. While restraint stress did not significantly affect the magnitude or class of the humoral response, it did alter the kinetics of the response. © 1991.
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收藏
页码:370 / 382
页数:13
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