CD4+ LYMPHOCYTE SUBSETS IN THE CEREBROSPINAL-FLUID OF MULTIPLE-SCLEROSIS AND NONINFLAMMATORY NEUROLOGICAL DISEASES

被引：12

作者：

ZAFFARONI, M ^{[1
]}

GALLO, L ^{[1
]}

GHEZZI, A ^{[1
]}

CAZZULLO, CL ^{[1
]}

机构：

[1] L SACCO HOSP VIALBA,IMMUNOHAEMATOL SERV,CYTOFLUORIMETRY LAB,MILAN,ITALY

来源：

JOURNAL OF NEUROLOGY | 1991年 / 238卷 / 04期

关键词：

MULTIPLE SCLEROSIS; CEREBROSPINAL FLUID; CD4+ CELL SUBSETS; IMMUNOFLUORESCENCE CYTOMETRY;

D O I：

10.1007/BF00314782

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied paired cerebrospinal fluid (CSF) and peripheral blood (PB) samples from 18 inactive multiple sclerosis (MS) patients and 10 with non-inflammatory neurological diseases. By means of a dual-colour cytofluorimetric micromethod we were able to count 1500 cells on average in each CSF sample. We found a significant reduction of CD45RA+ and CD4+CD45RA+ cells in the CSF of MS patients. Similarly, CD45RA+ and CD4+CD45RA+ CSF/PB ratios were lower compared with controls. The reduction of suppressor-inducer T-cells did not correlate with CD8+ cell levels in the CSF. The CD4+ subset ratio (CD4+CD45RA-/CD4+CD45RA+) was significantly increased in the CSF of MS patients. Our data suggest that the reduction of CD4+CD45RA+ cells in the PB is not due to a segregation of such cells in the CSF. Conversely, CSF changes reflect changes in the PB similar to these found for other T-cell subsets.

引用

页码：209 / 211

页数：3

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