BENZIMIDAZOLE RIBONUCLEOSIDES - OBSERVATION OF AN UNEXPECTED NITRATION WHEN PERFORMING NONAQUEOUS DIAZOTIZATIONS WITH TERT-BUTYL NITRITE

被引：12

作者：

DEVIVAR, RV

DRACH, JC

TOWNSEND, LB

机构：

[1] UNIV MICHIGAN,COLL PHARM,DEPT MED CHEM,ANN ARBOR,MI 48109

[2] UNIV MICHIGAN,COLL LITERATURE SCI & ARTS,DEPT CHEM,ANN ARBOR,MI 48109

[3] UNIV MICHIGAN,SCH DENT,DEPT BIOL & MAT SCI,ANN ARBOR,MI 48109

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(00)80628-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Mild, non-acidic conditions used in the non-aqueous diazotization of a 2-aminobenzimidazole nucleoside with t-butyl nitrite gave an unexpected 4-nitrobenzimidazol-2-one nucleoside which was not formed when primary alkyl nitrites were used. The isolated compounds were evaluated for activity against herpesviruses and for cytotoxicity against human foreskin fibroblast cells.

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页码：1105 / 1110

页数：6

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