RAPID MR-IMAGING OF A VASCULAR CHALLENGE TO FOCAL ISCHEMIA IN CAT BRAIN

被引：14

作者：

DECRESPIGNY, AJ

WENDLAND, MF

DERUGIN, N

VEXLER, ZS

MOSELEY, ME

机构：

[1] Department of Radiology, University of California, San Francisco, California, 94143, Box 0628

来源：

JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING | 1993年 / 3卷 / 03期

关键词：

BRAIN; ISCHEMIA; PERFUSION; MR; FUNCTIONAL STUDIES; OXYGEN; VASCULAR STUDIES;

D O I：

10.1002/jmri.1880030308

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Deoxygenated blood was effectively used as a magnetic resonance (MR) susceptibility contrast agent to distinguish perfused and nonperfused (ischemic) regions in a focal ischemia model in cat brain at 2 T. Modulation of cerebral blood oxygenation levels in response to apnea was followed in real time with T2*-weighted (gradient-recalled) echo-planar MR imaging. Signal loss in the T2*-weighted images occurred only in perfused tissues as blood became globally deoxygenated. These data complemented information from diffusion-weighted and contrast agent bolus-tracking images. In addition, observation of the signal recovery behavior on reventilation in both normal and ischemic brain offered potentially useful information about the state of the cerebral autoregulatory mechanism.

引用

页码：475 / 481

页数：7

共 16 条

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