THE FUNCTION OF DYNAMIN IN ENDOCYTOSIS

被引：131

作者：

DECAMILLI, P ^{[1
]}

TAKEI, K ^{[1
]}

MCPHERSON, PS ^{[1
]}

机构：

[1] YALE UNIV, SCH MED, HOWARD HUGHES MED INST, NEW HAVEN, CT 06510 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1995年 / 5卷 / 05期

关键词：

D O I：

10.1016/0959-4388(95)80059-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Temperature-sensitive shibire mutants of Drosophila melanogaster become rapidly paralyzed upon a shift to the restrictive temperature, which is due to a block in synaptic vesicle endocytosis. The shibire gene encodes the GTPase dynamin. Recent studies have shown that dynamin forms rings at the neck of invaginated clathrin-coated pits, and have suggested that a conformational change in the ring, which correlates with GTP hydrolysis, plays an essential role in vesicle fission.

引用

页码：559 / 565

页数：7

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