BIOCHEMICAL-PROPERTIES AND BIOLOGICAL EFFECTS OF P53

被引：175

作者：

HAFFNER, R

OREN, M

机构：

[1] Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1995年 / 5卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(95)90058-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Over the past year, insights have been made into the biochemistry and biological effects of p53. The high-resolution three-dimensional structure has been determined for the central core and carboxy-terminal domain of the protein, important p53 target genes (such as WAF1) have been identified, and insight has been gained into the relationship between p53-mediated growth arrest and apoptosis.

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页码：84 / 90

页数：7

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