ASYMMETRIC-SYNTHESIS .35. SYNTHESIS OF 2-METHYL 5-SUBSTITUTED PIPERIDINES FROM CHIRAL NON-RACEMIC LACTAMS

被引：21

作者：

VAREA, T

DUFOUR, M

MICOUIN, L

RICHE, C

CHIARONI, A

QUIRION, JC

HUSSON, HP

机构：

[1] CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE

[2] UNIV PARIS 05,FAC SCI PHARMACEUT & BIOL,CNRS,CHIM THERAPEUT LAB,F-75270 PARIS 06,FRANCE

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 07期

关键词：

ASYMMETRIC SYNTHESIS; 2-METHYL-5-SUBSTITUTED PIPERIDINES; DIASTEREOSELECTIVE ALKYLATION OF LACTAMS; PHENYLGLYCINOL DERIVATIVES;

D O I：

10.1016/0040-4039(94)02435-E

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 2-methyl-5-substituted piperidines in enantiomerically pure form has been synthesized from lactam 3a. The stereospecific alkylation involved a rigid amide enolate.

引用

页码：1035 / 1038

页数：4

共 9 条

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