REGULATORS OF CELL-DEATH

被引：626

作者：

KORSMEYER, SJ

机构：

[1] Division of Molecular Oncology, Department of Medicine and Pathology, Howard Hughes Medical Institute, Saint Louis

来源：

TRENDS IN GENETICS | 1995年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0168-9525(00)89010-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A novel oncogene-derived protein, Bcl-2, functions as a repressor of cell death in a genetic pathway of cellular suicide that appears to be common to all multicellular animals. A related protein that promotes cell death Bar, wrestles with Bcl-2 through conserved motifs, BH1 and BH2, establishing a set point for these deaths. In Bcl-2-deficient mice, the ratio of these molecules is reset, resulting in massive cell death in several cell types.

引用

页码：101 / 105

页数：5

共 42 条

[1] ASKEW DS, 1991, ONCOGENE, V6, P1915
[2] CLONING THE CHROMOSOMAL BREAKPOINT OF T(14-18) HUMAN LYMPHOMAS - CLUSTERING AROUND JH ON CHROMOSOME-14 AND NEAR A TRANSCRIPTIONAL UNIT ON 18
BAKHSHI, A
JENSEN, JP
GOLDMAN, P
WRIGHT, JJ
MCBRIDE, OW
EPSTEIN, AL
KORSMEYER, SJ
[J]. CELL, 1985, 41 (03) : 899 - 906
[3] BCL-X, A BCL-2-RELATED GENE THAT FUNCTIONS AS A DOMINANT REGULATOR OF APOPTOTIC CELL-DEATH
BOISE, LH
GONZALEZGARCIA, M
POSTEMA, CE
DING, LY
LINDSTEN, T
TURKA, LA
MAO, XH
NUNEZ, G
THOMPSON, CB
[J]. CELL, 1993, 74 (04) : 597 - 608
[4] NUCLEOTIDE-SEQUENCE OF A T(14,18) CHROMOSOMAL BREAKPOINT IN FOLLICULAR LYMPHOMA AND DEMONSTRATION OF A BREAKPOINT-CLUSTER REGION NEAR A TRANSCRIPTIONALLY ACTIVE LOCUS ON CHROMOSOME-18
CLEARY, ML
SKLAR, J
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (21) : 7439 - 7443
[5] COLES HSR, 1993, DEVELOPMENT, V118, P777
[6] EVAN AP, 1976, LAB INVEST, V35, P93
[7] SUPPRESSION OF APOPTOSIS ALLOWS DIFFERENTIATION AND DEVELOPMENT OF A MULTIPOTENT HEMATOPOIETIC-CELL LINE IN THE ABSENCE OF ADDED GROWTH-FACTORS
FAIRBAIRN, LJ
COWLING, GJ
REIPERT, BM
DEXTER, TM
[J]. CELL, 1993, 74 (05) : 823 - 832
[8] C-ELEGANS CELL-SURVIVAL GENE CED-9 ENCODES A FUNCTIONAL HOMOLOG OF THE MAMMALIAN PROTOONCOGENE BCL-2
HENGARTNER, MO
HORVITZ, HR
[J]. CELL, 1994, 76 (04) : 665 - 676
[9] CYTOTOXIC LYMPHOCYTES REQUIRE GRANZYME-B FOR THE RAPID INDUCTION OF DNA FRAGMENTATION AND APOPTOSIS IN ALLOGENEIC TARGET-CELLS
HEUSEL, JW
WESSELSCHMIDT, RL
SHRESTA, S
RUSSELL, JH
LEY, TJ
[J]. CELL, 1994, 76 (06) : 977 - 987
[10] BCL-2 FUNCTIONS IN AN ANTIOXIDANT PATHWAY TO PREVENT APOPTOSIS
HOCKENBERY, DM
OLTVAI, ZN
YIN, XM
MILLIMAN, CL
KORSMEYER, SJ
[J]. CELL, 1993, 75 (02) : 241 - 251

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