The synthesis of optically active pyridyl alcohols from the corresponding racemates by Catharanthus roseus cell cultures

被引：34

作者：

Takemoto, M

Achiwa, K

机构：

[1] School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, 422

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 12期

关键词：

D O I：

10.1016/0957-4166(95)00388-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A novel method for producing optically active pyridyl alcohols 1a-f from the corresponding racemates was developed. When racemic 3-pyridylphenylmethanol 1b is reacted with Catharanthus roseus cell cultures, (-)-1b is obtained in 96% yield with 100% ee.

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页码：2925 / 2928

页数：4

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