MARKEDLY PROLONGED THEOPHYLLINE HALF-LIFE IN LIVER-FAILURE

被引：7

作者：

BASELT, RC ^{[1
]}

ALBERTSON, TE ^{[1
]}

机构：

[1] UNIV CALIF DAVIS, DAVIS MED CTR, DEPT MED, DAVIS, CA 95616 USA

来源：

JOURNAL OF ANALYTICAL TOXICOLOGY | 1982年 / 6卷 / 02期

关键词：

D O I：

10.1093/jat/6.2.62

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Theophylline [used in the treatment of bronchospasm] toxicity developed within 48 h of admission in a 63-yr-old alcoholic male who presented with shortness of breath, edema and lethargy. Using liquid chromatography, a serum theophylline half-life of 134 h was observed following discontinuation of the drug. The effect of hepatic disease on theophylline clearance and the need for frequent monitoring of plasma theophylline concentrations in cirrhotic patients are stressed.

引用

页码：62 / 63

页数：2

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