SIGNAL TRANSDUCTION AND GENE-REGULATION THROUGH THE PHOSPHORYLATION OF 2 REGULATORY COMPONENTS - THE MOLECULAR-BASIS FOR THE OSMOTIC REGULATION OF THE PORIN GENES

被引：210

作者：

MIZUNO, T ^{[1
]}

MIZUSHIMA, S ^{[1
]}

机构：

[1] UNIV TOKYO,INST APPL MICROBIOL,BUNKYO KU,TOKYO 113,JAPAN

来源：

MOLECULAR MICROBIOLOGY | 1990年 / 4卷 / 07期

关键词：

D O I：

10.1111/j.1365-2958.1990.tb00681.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Expression of Escherichia coli outer‐membrane porin proteins (OmpF and OmpC) is regulated by the osmolarity of the medium. EnvZ and OmpR, which are positive regulatory factors for the transcriptional osmotic regulation of the ompF and ompC genes, belong to a group of two‐component regulatory factors that respond to a variety of environmental stimuli in bacteria. EnvZ‐OmpR phosphotransfer was revealed to be involved in signal transduction in response to an osmotic stimulus, and to play a crucial physiological role in the consequent osmotic activation of the porin genes. Based on the various lines of experimental evidence, a model is proposed for the molecular mechanism underlying the osmotic regulation through phosphorylation of the activator (OmpR) by the membrane‐locate kinase (EnvZ). Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：1077 / 1082

页数：6

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