NEW DEGRADATION PRODUCT OF DES-GLY10-NH2-LH-RH-ETHYLAMIDE (FERTIRELIN) IN AQUEOUS-SOLUTION

被引：10

作者：

OKADA, J ^{[1
]}

SEO, T ^{[1
]}

KASAHARA, F ^{[1
]}

TAKEDA, K ^{[1
]}

KONDO, S ^{[1
]}

机构：

[1] TAKEDA CHEM IND LTD,CHEM LABS,YODOGAWA KU,OSAKA 532,JAPAN

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1991年 / 80卷 / 02期

关键词：

D O I：

10.1002/jps.2600800217

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new degradation product was found in an ampule preparation of des-Gly10-NH2-LH-RH-ethylamide (fertirelin) stored at room temperatures. The same product, produced at a higher temperature, was identified to be a diastereomeric mixture of cyclo(His-Trp) by proton nuclear magnetic resonance spectroscopy, mass spectrometry, and comparison with authentic samples. Preferred conformations regarding substituents on the diketopiperazine ring of cyclo(His-Trp) were calculated using coupling constants between vicinal protons.

引用

页码：167 / 170

页数：4

共 8 条

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