ACETYL-L-CARNITINE INCREASES CYTOCHROME-OXIDASE SUBUNIT-I MESSENGER-RNA CONTENT IN HYPOTHYROID RAT-LIVER

被引：17

作者：

GADALETA, MN

PETRUZZELLA, V

FRACASSO, F

FERNANDEZSILVA, P

CANTATORE, P

机构：

[1] UNIV BARI, DIPARTMENTO BIOCHIM & BIOL MOLEC, I-70124 BARI, ITALY

[2] CTR STUDI MITOCONDRI & METAB ENERGET, BARI, ITALY

来源：

FEBS LETTERS | 1990年 / 277卷 / 1-2期

关键词：

MITOCHONDRIAL DNA TRANSCRIPTION; HYPOTHYROID RAT LIVER; ACETYL-L-CARNITINE;

D O I：

10.1016/0014-5793(90)80841-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of acetyl-L-carnitine on the quantity of the messenger RNA for the subunit I of cytochrome oxidase in the liver mitochondria of hypothyroid rat was measured by Northern blot and solution hybridization. Three hours after pre-treatment of hypothyroid rat with acetyl-L-carnitine, the level of the transcript increased strongly. This effect was also obtained when acetyl-L-carnitine was administered to T3 pre-treated hypothyroid rats. These results add further evidence to the suggestion that acetyl-L-carnitine is able to stimulate mitochondrial transcription under altered metabolic conditions.

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页码：191 / 193

页数：3

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