A COMPARISON OF MASKING EFFECTS OF HALOPERIDOL VERSUS MOLINDONE IN TARDIVE-DYSKINESIA

被引：17

作者：

GLAZER, WM ^{[1
]}

HAFEZ, H ^{[1
]}

机构：

[1] NASHUA BROOKSIDE HOSP,NASHUA,NH 03063

来源：

SCHIZOPHRENIA RESEARCH | 1990年 / 3卷 / 5-6期

关键词：

Haloperidol; Molindone; Neuroleptic; Tardive dyskinesia;

D O I：

10.1016/0920-9964(90)90016-Z

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

An experimental method was utilized to compare the masking effects of two neuroleptic agents-molindone and haloperidol-on 18 neuroleptic-treated schizophrenic patients exhibiting operationally defined withdrawal-exacerbated tardive dyskinesia. After a week on one of these two medications at preestablished doses equivalent to that of the pre-study neuroleptic, molindone-masked total AIMS scores by significantly less (12%) than haloperidol (27%). Similarly, during a second week when the dose of these neuroleptics was equivalent to 200% that of the pre-study dose, molindone masked the total AIMS score significantly less (23%) as compared to haloperidol (53%). Several interpretations of this findings are considered. This study demonstrates the feasibility of a method that may offer a model for understanding pharmacological differences among neuroleptic medications. © 1990.

引用

页码：315 / 320

页数：6

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