ALPHA-INHIBIN IS A TUMOR-SUPPRESSOR GENE WITH GONADAL SPECIFICITY IN MICE

被引：824

作者：

MATZUK, MM

FINEGOLD, MJ

SU, JGJ

HSUEH, AJW

BRADLEY, A

机构：

[1] BAYLOR COLL MED, DEPT PATHOL, HOUSTON, TX 77030 USA

[2] STANFORD UNIV, DEPT GYNECOL OBSTET, DIV REPROD BIOL, STANFORD, CA 94305 USA

来源：

NATURE | 1992年 / 360卷 / 6402期

关键词：

D O I：

10.1038/360313a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The inhibins are alpha:beta heterodimeric growth factors that are members of the transforming growth factor-beta family. To understand the physiological roles of the inhibins in mammalian development and reproduction, a targeted deletion of the alpha-inhibin gene was generated by homologous recombination in mouse embryonic stem cells. Mice homozygous for the null allele (inhibin-deficient) initially develop normally but every mouse ultimately develops mixed or incompletely differentiated gonadal stromal tumours either unilaterally or bilaterally. Inhibin is thus a critical negative regulator of gonadal stromal cell proliferation and the first secreted protein identified to have tumour-suppressor activity.

引用

页码：313 / 319

页数：7

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