PRIMARY STRUCTURES OF 2 SUBUNITS OF NADH-UBIQUINONE REDUCTASE FROM NEUROSPORA-CRASSA CONCERNED WITH NADH-OXIDATION - RELATIONSHIP TO A SOLUBLE NAD-REDUCING HYDROGENASE OF ALCALIGENES-EUTROPHUS

被引：51

作者：

PREIS, D

WEIDNER, U

CONZEN, C

AZEVEDO, JE

NEHLS, U

ROHLEN, D

VANDERPAS, J

SACKMANN, U

SCHNEIDER, R

WERNER, S

WEISS, H

机构：

[1] UNIV DUSSELDORF,INST BIOCHEM,UNIV STR 1,W-4000 DUSSELDORF 1,GERMANY

[2] UNIV MUNICH,INST PHYSIOL CHEM,W-8000 MUNICH 2,GERMANY

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1090卷 / 01期

关键词：

NADH UBIQUINONE REDUCTASE; COMPLEX-I; NAD(H)-BINDING SITE; FMN-BINDING SITE; IRON-SULFUR CLUSTER; (NEUROSPORA-CRASSA);

D O I：

10.1016/0167-4781(91)90049-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The primary structures of the nuclear-encoded 51 kDa and 78 kDa subunits of the respiratory chain NADH: ubiquinone reductase (complex I) from Neurospora crassa mitochondria were determined by sequencing cDNA and the N-terminus of the mature proteins. Both subunits are related to the soluble NAD-reducing hydrogenase of the bacterium Alcaligenes eutrophus. Sequence comparison between these subunits, the corresponding subunits of the bovine complex I and the bacterial NAD-reducing hydrogenase further confirms the binding sites of NAD(H), FMN and three iron-sulfur clusters.

引用

页码：133 / 138

页数：6

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[1] SEQUENCES IMPORTANT FOR GENE-EXPRESSION IN FILAMENTOUS FUNGI [J].