ALTERATION OF CALCIUM INFLUX IN RAT CORTICAL SYNAPTOSOMES BY SOMAN

被引：9

作者：

HAMILTON, MG

POSAVAD, C

机构：

[1] Pharmacology and Therapeutics, Biomedical Defence Section, Defence Research Establishment Suffield, Medicine Hat, AB, TOJ 2N0

来源：

NEUROREPORT | 1991年 / 2卷 / 05期

关键词：

SOMAN; CALCIUM INFLUX; NEUROPATHOLOGY; CALCIUM FLUX AND ORGANOPHOSPHATES; VOLTAGE SENSITIVE CALCIUM CHANNELS;

D O I：

10.1097/00001756-199105000-00015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

POISONING by soman causes changes in brain activity leading to neuronal death in several brain areas. We investigated whether disruption of normal Ca2+ homeostasis was sufficient to account for at least some of the OP-induced neurotoxicity. Beginning 24 h after a challenge with soman (1 or 4 LD50) K+-stimulated synaptosomal Ca2+ influx was significantly elevated above that in control animals. Neuronal Ca2+ influx remained elevated for two days after 1 LD50 of soman and at least 7 days after 4 LD50. The effect was specific for depolarization induced influx as there was no effect on resting (5 mM K+) Ca2+ accumulation. These results suggest thatincreased intracellular Ca2+ may contribute to the neuronal degeneration and neurotoxicity observed after poisoning with soman.

引用

页码：273 / 276

页数：4

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