EXCITATORY AMINO-ACID REGULATION OF GONADOTROPIN-SECRETION - MODULATION BY STEROID-HORMONES

被引：57

作者：

BRANN, DW ^{[1
]}

MAHESH, VB ^{[1
]}

机构：

[1] MED COLL GEORGIA, DEPT PHYSIOL & ENDOCRINOL, AUGUSTA, GA 30912 USA

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1992年 / 41卷 / 3-8期

关键词：

D O I：

10.1016/0960-0760(92)90436-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Excitatory amino acids (EAAs) can potently modulate gonadotropin secretion in the male and monkey. In the present study we examined the effect of EAAs on luteinzing hormone (LH) and follicle-stimulating hormone (FSH) in the female rat under low estrogen (ovariectomized) and high estrogen (proestrus) backgrounds. In ovariectomized immature female rats N-methyl-D-aspartate (NMDA) inhibited LH but not FSH secretion at 30 min post-injection. In contrast, NMDA potently stimulated LH but not FSH secretion when administered on proestrus to adult female rats. Both glutamate and kainate were also found to stimulate LH but not FSH secretion in estrogen-treated ovariectomized immature rats. This study suggests that EAA neurotransmission may be an important component in the expression of gonadotropin surges and that EAA effects appear to be subject to gonadal steroid regulation.

引用

页码：847 / 850

页数：4

共 27 条

[1] ACTIONS OF ACIDIC AMINO-ACIDS ON THE EXCITABILITY OF MEDIAL HYPOTHALAMIC NEURONS IN THE RAT [J].

ARNAULD, E ;

LAYTON, BS ;

PADJEN, AL ;

RENAUD, LP .

NEUROENDOCRINOLOGY, 1983, 37 (03) :184-192

[2] DIRECT ACTIVATION OF GONADOTROPIN-RELEASING HORMONE-SECRETION THROUGH DIFFERENT RECEPTORS TO NEUROEXCITATORY AMINO-ACIDS [J].

BOURGUIGNON, JP ;

GERARD, A ;

FRANCHIMONT, P .

NEUROENDOCRINOLOGY, 1989, 49 (04) :402-408

[3] ENDOGENOUS EXCITATORY AMINO-ACID REGULATION OF THE PROGESTERONE-INDUCED LH AND FSH SURGE IN ESTROGEN-PRIMED OVARIECTOMIZED RATS [J].

BRANN, DW ;

MAHESH, VB .

NEUROENDOCRINOLOGY, 1991, 53 (01) :107-110

[4] ENDOGENOUS EXCITATORY AMINO-ACID INVOLVEMENT IN THE PREOVULATORY AND STEROID-INDUCED SURGE OF GONADOTROPINS IN THE FEMALE RAT [J].

BRANN, DW ;

MAHESH, VB .

ENDOCRINOLOGY, 1991, 128 (03) :1541-1547

[5] REGULATION OF HYPOTHALAMIC GONADOTROPIN-RELEASING-HORMONE AND NEUROPEPTIDE-Y CONCENTRATIONS BY PROGESTERONE AND CORTICOSTEROIDS IN IMMATURE RATS - CORRELATION WITH LUTEINIZING-HORMONE AND FOLLICLE-STIMULATING-HORMONE RELEASE [J].

BRANN, DW ;

MCDONALD, JK ;

PUTNAM, CD ;

MAHESH, VB .

NEUROENDOCRINOLOGY, 1991, 54 (05) :425-432

[6] DETAILED EXAMINATION OF THE MECHANISM AND SITE OF ACTION OF PROGESTERONE AND CORTICOSTEROIDS IN THE REGULATION OF GONADOTROPIN-SECRETION - HYPOTHALAMIC GONADOTROPIN-RELEASING-HORMONE AND CATECHOLAMINE INVOLVEMENT [J].

BRANN, DW ;

MAHESH, VB .

BIOLOGY OF REPRODUCTION, 1991, 44 (06) :1005-1015

[7] CHARACTERIZATION AND POSSIBLE OPIOID MODULATION OF N-METHYL-D-ASPARTIC ACID-INDUCED INCREASES IN SERUM LUTEINIZING-HORMONE LEVELS IN THE DEVELOPING MALE-RAT [J].

CICERO, TJ ;

MEYER, ER ;

BELL, RD .

LIFE SCIENCES, 1988, 42 (18) :1725-1732

[8] ROLE OF OPIOID-PEPTIDES IN PULSATILE RELEASE OF GONADOTROPINS AND PROLACTIN IN THE RAT [J].

DECASTRO, JCB ;

KHORRAM, O ;

PETROVIC, SL ;

MCCANN, SM .

BRAIN RESEARCH BULLETIN, 1987, 19 (05) :539-544

[9] EFFECT OF N-METHYL-D,L-ASPARTATE ON LUTEINIZING-HORMONE SECRETION IN OVARIECTOMIZED EWES IN THE ABSENCE AND PRESENCE OF ESTRADIOL [J].

ESTIENNE, MJ ;

SCHILLO, KK ;

HILEMAN, SM ;

GREEN, MA ;

HAYES, SH .

BIOLOGY OF REPRODUCTION, 1990, 42 (01) :126-130

[10] N-METHYL-D,L-ASPARTATE ELICITS HYPOTHALAMIC GONADOTROPIN-RELEASING HORMONE-RELEASE IN PREPUBERTAL MALE RHESUS-MONKEYS (MACACA-MULATTA) [J].

GAY, VL ;

PLANT, TM .

ENDOCRINOLOGY, 1987, 120 (06) :2289-2296

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