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EFFECT OF CU-2+-ASCORBIC ACID ON LIPID-PEROXIDATION, MG-2+-ATPASE ACTIVITY AND SPECTRIN OF RBC MEMBRANE AND REVERSAL BY ERYTHROPOIETIN

被引：17
作者：
CHATTOPADHYAY, A
DASCHOUDHURY, T
BASU, MK
DATTA, AG
机构：
[1] INDIAN INST CHEM BIOL,4 RAJA SC MULLICK RD,CALCUTTA 700032,W BENGAL,INDIA
[2] GUHA INST BIOCHEM,CALCUTTA 700029,INDIA
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 1992年 / 118卷 / 01期
关键词：
ERYTHROPOIETIN; LIPID PEROXIDATION; MG-2+-ATPASE; CU-2+-ASCORBIC ACID; RBC MEMBRANE; SPECTRIN;
D O I：
10.1007/BF00249691
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The effect of erythropoietin (Ep), a glycoprotein hormone, has been studied on lipid peroxidation induced by Cu2+ and ascorbate in vitro, Mg2+ ATPase activity and spectrin of RBC membrane. Our present investigation reveals that Cu2+ and ascorbic acid increases lipid peroxidation of RBC membrane significantly. It has further been observed that under the same experimental condition spectrin, a major cytoskeleton membrane protein, and Mg2+-ATPase activity of RBC membrane decrease significantly. However, exogenous administration of Ep completely restores lipid peroxidation and Mg2+-ATPase activity and partially recovers spectrin of RBC membrane.
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页码：23 / 30
页数：8
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