MOLECULAR RECOGNITION AT SELF-ASSEMBLED MONOLAYERS - OPTIMIZATION OF SURFACE FUNCTIONALIZATION

被引:284
作者
SPINKE, J
LILEY, M
SCHMITT, FJ
GUDER, HJ
ANGERMAIER, L
KNOLL, W
机构
[1] BOEHRINGER MANNHEIM GMBH,W-8132 TUTZING,GERMANY
[2] INST PHYS & CHEM RES,FRONTIER RES PROGRAM,SAITAMA 35101,JAPAN
关键词
D O I
10.1063/1.465447
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Sulfur-based molecules containing biotin and hydroxyl groups have been used to create a wide variety of self-assembled monolayers on gold surfaces. Surface plasmon resonance has been used to study in situ the binding of streptavidin to these monolayers from solution. The self-assembled monolayers allow a high degree of control over the surface properties. The choice of an appropriate biotin-containing molecule, with a spacer segment, and the dilution of this molecule within the monolayer by hydroxythiols, allows optimization of the binding properties of the monolayer-nonspecific interactions between streptavidin and the surface are below detection limits, and specific binding between the streptavidin and biotin groups can be maximized.
引用
收藏
页码:7012 / 7019
页数:8
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