HYPOTHESIS - LOW SERUM-CHOLESTEROL, SUICIDE, AND INTERLEUKIN-2

被引：49

作者：

PENTTINEN, J

机构：

来源：

AMERICAN JOURNAL OF EPIDEMIOLOGY | 1995年 / 141卷 / 08期

关键词：

ATHEROSCLEROSIS; CHOLESTEROL; INTERLEUKIN-2; SUICIDE;

D O I：

10.1093/oxfordjournals.aje.a117492

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

An excess mortality for violence (suicides and injuries) has been observed following the use of cholesterol lowering drugs. It has been suggested that low cholesterol is associated with depression by modifying the serotonin metabolism. In this paper, a new hypothesis concerning the association among serum lipids, depression, and atherosclerosis is proposed. The hypothesis is based on epidemiologic evidence concerning serum lipids, depression, violent deaths, and atherosclerosis. It is also based on previous results concerning a cytokine, interleukin-2. Recent observations indicate that interleukin-2 has an important role in lipid metabolism, depression, and atherosclerosis.

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页码：716 / 718

页数：3

相关论文

共 25 条

[1]

Baron David A., 1993, Journal of the American Osteopathic Association, V93, P799

[2] THE ASSOCIATION BETWEEN CHOLESTEROL AND DEATH FROM INJURY [J].

CUMMINGS, P ;

PSATY, BM .

ANNALS OF INTERNAL MEDICINE, 1994, 120 (10) :848-855

[3] LOW SERUM-CHOLESTEROL AND SUICIDE [J].

ENGELBERG, H .

LANCET, 1992, 339 (8795) :727-729

[4] INDUCTION OF T-CELL ACTIVATION BY OXIDIZED LOW-DENSITY-LIPOPROTEIN [J].

FROSTEGARD, J ;

WU, RH ;

GISCOMBE, R ;

HOLM, G ;

LEFVERT, AK ;

NILSSON, J .

ARTERIOSCLEROSIS AND THROMBOSIS, 1992, 12 (04) :461-467

[5]

HANSSON GK, 1989, AM J PATHOL, V135, P169

[6] APOLIPOPROTEIN-E AND LIPOPROTEIN-LIPASE REDUCE MACROPHAGE DEGRADATION OF OXIDIZED VERY LOW-DENSITY-LIPOPROTEIN (VLDL), BUT INCREASE CELLULAR DEGRADATION OF NATIVE VLDL [J].

KEIDAR, S ;

KAPLAN, M ;

ROSENBLAT, M ;

BROOK, GJ ;

AVIRAM, M .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1992, 41 (11) :1185-1192

[7] LOW SERUM-CHOLESTEROL CONCENTRATION AND SHORT-TERM MORTALITY FROM INJURIES IN MEN AND WOMEN [J].

LINDBERG, G ;

RASTAM, L ;

GULLBERG, B ;

EKLUND, GA .

BRITISH MEDICAL JOURNAL, 1992, 305 (6848) :277-279

[8] NEUROENDOCRINE EFFECTS OF SUBCUTANEOUS INTERLEUKIN-2 INJECTION IN CANCER-PATIENTS [J].

LISSONI, P ;

BARNI, S ;

ROVELLI, F ;

CRISPINO, S ;

FUMAGALLI, G ;

PESCIA, S ;

VAGHI, M ;

CAMESASCA, G ;

TANCINI, G .

TUMORI, 1991, 77 (03) :212-215

[9] DECREASE IN CHOLESTEROL LEVELS DURING THE IMMUNOTHERAPY OF CANCER WITH INTERLEUKIN-2 [J].

LISSONI, P ;

BRIVIO, F ;

PITTALIS, S ;

PEREGO, MS ;

ARDIZZOIA, A ;

MAURI, O ;

BARNI, S ;

CRISPINO, S ;

TANCINI, G .

BRITISH JOURNAL OF CANCER, 1991, 64 (05) :956-958

[10] SIGNIFICANTLY INCREASED EXPRESSION OF T-CELL ACTIVATION MARKERS (INTERLEUKIN-2 AND HLA-DR) IN DEPRESSION - FURTHER EVIDENCE FOR AN INFLAMMATORY PROCESS DURING THAT ILLNESS [J].

MAES, M ;

STEVENS, WJ ;

DECLERCK, LS ;

BRIDTS, CH ;

PEETERS, D ;

SCHOTTE, C ;

COSYNS, P .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1993, 17 (02) :241-255