ENDOTHELIN AND EICOSANOID SYNTHESIS IN CULTURED MESANGIAL CELLS

被引:38
作者
ZOJA, C [1 ]
BENIGNI, A [1 ]
RENZI, D [1 ]
PICCINELLI, A [1 ]
PERICO, N [1 ]
REMUZZI, G [1 ]
机构
[1] MARIO NEGRI INST PHARMACOL RES, VIA GAVAZZENI 11, I-24100 BERGAMO, ITALY
关键词
D O I
10.1038/ki.1990.67
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
We investigated the effect of endothelin on the generation of eicosanoids, which are known to regulate basal and stimulated mesangial cell tone. The results showed that endothelin is a potent stimulus of prostaglandin E2 (PGE2), prostacyclin (PGI2), and thromboxane A2 (TxA2) synthesis by bovine mesangial cells. Percentage increases in eicosanoid synthesis induced by endothelin (10-10 to 10-6 M), were 50 to 275% for PGE2, 28 to 168% for PGI2 and 42 to 111% for TxA2, respectively. Endothelin-induced eicosanoid synthesis in mesangial cells was concentration, but not time dependent. Aspirin (500 μM) completely prevented endothelin-induced eicosanoid synthesis. The calcium entry blocker nitrendipine (10-8 M) failed to inhibit endothelin-induced eicosanoid synthesis. These data suggest that endothelin-induced changes in renal circulation and glomerular function in normal and disease conditions may be modulated by the concomitant stimulation of mesangial eicosanoid synthesis.
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收藏
页码:927 / 933
页数:7
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