INTRALESIONAL IMMUNOTHERAPY OF BRAIN-TUMORS WITH COMBINED CORYNEBACTERIUM-PARVUM AND RECOMBINANT INTERLEUKIN-2 IN MICE

被引：9

作者：

CONLEY, FK ^{[1
]}

ADLER, JR ^{[1
]}

DUNCAN, JA ^{[1
]}

KENNEDY, JD ^{[1
]}

SUTTON, RC ^{[1
]}

机构：

[1] VET ADM MED CTR,PALO ALTO,CA 94304

来源：

JOURNAL OF THE NATIONAL CANCER INSTITUTE | 1990年 / 82卷 / 16期

关键词：

D O I：

10.1093/jnci/82.16.1340

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Clinical observations and experimental work suggested that inflammatory cells attracted to the brain exert a nonspecific antineoplastic effect. Intralesional treatment of implanted malignant murine brain tumors (KHT sarcomas) with killed Corynebacterium parvum produced an inflammatory cell infiltrate and increased survival in C3H mice relative to that in untreated control C3H mice. This antitumor effect was enhanced when recombinant interleu-kin-2 was sequentially added as a second intralesional immunomodifier. A high percentage of mice so treated were cured. Inflammatory cells in the brains of treated mice divided for 1-2 weeks, and metabolic activity of astrocytes increased. These findings form the basis for a recently initiated immunotherapy protocol in patients with recurrent glio-blastoma multiforme. [J Natl Cancer Inst 82:1340-1344, 1990] © 1990 Oxford University Press.

引用

页码：1340 / 1344

页数：5

共 24 条

[1] INTRATUMORAL LAK CELL AND INTERLEUKIN-2 THERAPY OF HUMAN GLIOMAS [J].