CYCLIC PHENYL CARBAMATES AND THEIR ACTION ON ACETYLCHOLINESTERASE

被引：17

作者：

AMSTUTZ, R

ENZ, A

MARZI, M

BOELSTERLI, J

WALKINSHAW, M

机构：

[1] Sandoz Pharma Ltd, Präklinische Forschung, Basel

来源：

HELVETICA CHIMICA ACTA | 1990年 / 73卷 / 03期

关键词：

D O I：

10.1002/hlca.19900730323

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cyclic Phenyl Carbamates and Their Action on Acetylcholinesterase Several six‐, seven‐, and eight‐membered cyclic phenyl carbamates of the miotin type have been synthesised and their in vitro potency as inhibitors of acetylcholinesterase determined. The eight‐membered rings were found to be the most potent and are comparable with physostigrnin or miotin. It was concluded that, for maximum potency, the orientation of the carbamate group relative to the aromatic plane has to be close to orthogonal. Copyright © 1990 Verlag GmbH & Co. KGaA, Weinheim

引用

页码：739 / 753

页数：15

共 14 条

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