INVOLVEMENT OF NMDA RECEPTORS IN NONCONVULSIVE EPILEPSY IN WAG/RIJ RATS

被引：43

作者：

PEETERS, BWMM ^{[1
]}

VANRIJN, CM ^{[1
]}

VOSSEN, JMH ^{[1
]}

COENEN, AML ^{[1
]}

机构：

[1] UNIV NIJMEGEN,DEPT COMPARAT & PHYSIOL PSYCHOL,6500 HE NIJMEGEN,NETHERLANDS

来源：

LIFE SCIENCES | 1990年 / 47卷 / 06期

关键词：

D O I：

10.1016/0024-3205(90)90612-U

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The involvement of the NMDA receptor in spontaneous non-convulsive epilepsy was studied by intracerebroventricular injections of APH and NMDA in WAG/Rij rats. The WAG/Rij rat strain is recognized as an animal model for human absence epilepsy. EEG registrations showed that APH (5 nmol/5 ul; 25 nmol/5 ul; 50 nmol/5 ul) causes a dose-dependent decrease in the number and mean duration of the spike-wave discharges, while NMDA (50 pmol/5 ul; 500 pmol/5 ul; 5 nmol/5 ul) induces a dose-dependent increase in the number. The effects of NMDA (5 nmol/5 ul) can be blocked completely by APH (50 nmol/5 ul). These results suggest an involvement of the NMDA receptor in experimental non-convulsive epilepsy, observed in the WAG/Rij model. © 1990.

引用

页码：523 / 529

页数：7

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