TIME COURSE AND INHIBITION OF SAPONIN-INDUCED HEMOLYSIS

被引：17

作者：

TAKECHI, M ^{[1
]}

SHIMADA, S ^{[1
]}

TANAKA, Y ^{[1
]}

机构：

[1] SHIMADA PHARMACEUT INST,SUMINOE KU,OSAKA 559,JAPAN

来源：

PLANTA MEDICA | 1992年 / 58卷 / 02期

关键词：

HEMOLYSIS; TIME COURSE; INHIBITION; SAPONIN; SAPOGENIN; CHOLESTEROL;

D O I：

10.1055/s-2006-961413

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Hemolytic activities of 3 steroid saponins reached plateaus within 5 min, whereas those of 4 triterpenoid saponins did not within 60 min. Erythrocytes pretreated with a low concentration of tigogenin were resistant to hemolysis of some of these saponins, but those pretreated with hecogenin or tomatidine were as sensitive as non-treated erythrocytes. Therefore, the ketone group of hecogenin or the amino group of tomatidine would weaken the interactions between the erythrocytes and these sapogenins. Furthermore, incubations of these saponins with a small amount of cholesterol diminished the hemolytic activities.

引用

页码：128 / 130

页数：3

共 7 条

[1] HEMOLYSIS CAUSED BY POLYOXYETHYLENE-DERIVED SURFACTANTS - EVIDENCE FOR PEROXIDE PARTICIPATION [J].