INCREASED FREQUENCY OF CALCIUM WAVES IN XENOPUS-LAEVIS OOCYTES THAT EXPRESS A CALCIUM-ATPASE

被引：147

作者：

CAMACHO, P

LECHLEITER, JD

机构：

[1] Department of Neuroscience, University of Virginia, Health Sciences Center, Charlottesville

来源：

SCIENCE | 1993年 / 260卷 / 5105期

关键词：

D O I：

10.1126/science.8385800

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

When inositol 1,4,5-trisphosphate (IP3) receptors are activated, calcium is released from intracellular stores in excitatory propagating waves that annihilate each other upon collision. The annihilation phenomenon suggests the presence of an underlying refractory period that controls excitability. Enhanced calcium-adenosine triphosphatase (ATPase) activity might alter the refractory period of calcium release. Expression of messenger RNA encoding the avian calcium-ATPase (SERCA1) in Xenopus laevis oocytes increased the frequency of IP3-induced calcium waves and narrowed the width of individual calcium waves. The effect of SERCA1 expression on calcium wave frequency was dependent on the concentration of IP3 and was larger at higher (1 muM) than at lower (0.1 muM) concentrations of IP3. The results demonstrate that calcium pump activity can control IP3-mediated calcium signaling.

引用

页码：226 / 229

页数：4

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