STRUCTURE AND FUNCTION OF POLY(ADP-RIBOSE) POLYMERASE

被引：185

作者：

DEMURCIA, G

SCHREIBER, V

MOLINETE, M

SAULIER, B

POCH, O

MASSON, M

NIEDERGANG, C

DEMURCIA, JM

机构：

[1] INST BIOL MOLEC & CELLULAIRE,DIV CELLULAIRE & DEV,UNITE MECANISMES,F-67084 STRASBOURG,FRANCE

[2] UNIV RENNES 1,BIOL & GENET DEV LAB,CNRS,F-35042 RENNES,FRANCE

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 1994年 / 138卷 / 1-2期

关键词：

ZINC FINGER PROTEIN; NUCLEAR LOCALIZATION SIGNAL; BASE EXCISION REPAIR; MICROINJECTION; DOMINANT-NEGATIVE MUTANT; NAD METABOLISM;

D O I：

10.1007/BF00928438

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Poly(ADP-ribose) polymerase (PARP) participates in the intricate network of systems developed by the eukaryotic cell to cope with the numerous environmental and endogenous genetoxic agents. Cloning of the PARP gene has allowed the development of genetic and molecular approaches to elucidate the structure and the function of this abundant and highly conserved enzyme. This article summarizes our present knowledge in this field.

引用

页码：15 / 24

页数：10

共 39 条

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Althaus F R, 1987, Mol Biol Biochem Biophys, V37, P1

[2] HUMAN NUCLEAR NAD+ ADP-RIBOSYLTRANSFERASE(POLYMERIZING) - ORGANIZATION OF THE GENE [J].