AGE-DEPENDENT DECREASE OF ALPHA-2-ADRENERGIC RECEPTOR NUMBER IN HUMAN-PLATELETS

被引：78

作者：

BRODDE, OE ^{[1
]}

ANLAUF, M ^{[1
]}

GRABEN, N ^{[1
]}

BOCK, KD ^{[1
]}

机构：

[1] UNIV ESSEN GESAMTHSCH, MED KLIN & POLIKLIN, DIV RENAL & HYPERTENS DIS, D-4300 ESSEN 1, FED REP GER

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1982年 / 81卷 / 02期

关键词：

D O I：

10.1016/0014-2999(82)90456-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In 36 healthy subjects of various ages (14-76 yr) the number of .alpha.2-adrenergic receptors in platelets, as determined by [3H]yohimbine binding, and plasma catecholamine levels were measured. A highly significant negative correlation (r = - 0.666, P < 0.001) between the number of .alpha.2-adrenergic receptors and age was found, but plasma catecholamine concentrations increased with increasing age. Reduced responses in the elderly to adrenergic stimuli may be due to reduced number of adrenergic receptors.

引用

页码：345 / 347

页数：3