INACTIVATION OF CYTOCHROME-P-450 AND PRODUCTION OF N-ALKYLATED PORPHYRINS CAUSED IN ISOLATED HEPATOCYTES BY SUBSTITUTED DIHYDROPYRIDINES - STRUCTURAL REQUIREMENTS FOR LOSS OF HEME AND ALKYLATION OF THE PYRROLE NITROGEN ATOM

被引：40

作者：

DEMATTEIS, F

HOLLANDS, C

GIBBS, AH

DESA, N

RIZZARDINI, M

机构：

来源：

FEBS LETTERS | 1982年 / 145卷 / 01期

关键词：

D O I：

10.1016/0014-5793(82)81212-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：87 / 92

页数：6

共 33 条

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[2]

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[6] ALTERATION OF THE PORPHYRIN NUCLEUS OF CYTOCHROME-P-450 CAUSED IN THE LIVER BY TREATMENT WITH ALLYL-CONTAINING DRUGS - IS THE MODIFIED PORPHYRIN N-SUBSTITUTED [J].

DEMATTEIS, F ;

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BIOCHEMICAL JOURNAL, 1979, 183 (01) :99-103

[7] LIVER PRODUCTION OF N-ALKYLATED PORPHYRINS CAUSED IN MICE BY TREATMENT WITH SUBSTITUTED DIHYDROPYRIDINES - EVIDENCE THAT THE ALKYL GROUP ON THE PYRROLE NITROGEN ATOM ORIGINATES FROM THE DRUG [J].

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[8]

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[9] STIMULATION OF PATHWAY OF PORPHYRIN SYNTHESIS IN LIVER OF RATS AND MICE BY GRISEOFULVIN, 3,5-DIETHOXYCARBONYL-1,4-DIHYDROCOLLIDINE AND RELATED DRUGS - EVIDENCE FOR 2 BASICALLY DIFFERENT MECHANISMS [J].

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GIBBS, AH .

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[10] CONVERSION OF LIVER HEME INTO N-SUBSTITUTED PORPHYRINS OR GREEN PIGMENTS [J].

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WEERASINGHE, S .

FEBS LETTERS, 1980, 119 (01) :109-112

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