A NEW APPROACH TO THE ANALYSIS OF COMPLEX DOSE-RESPONSE RELATIONSHIPS - A MULTIVARIATE STUDY OF OCTOPAMINE ACTION ON THE LEECH LEYDIG NEURON

被引：2

作者：

DEAN, JA ^{[1
]}

FORD, MG ^{[1
]}

LEAKE, LD ^{[1
]}

机构：

[1] PORTSMOUTH POLYTECH, DEPT BIOL SCI, KING HENRY I ST, PORTSMOUTH PO1 2DY, ENGLAND

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY | 1985年 / 82卷 / 01期

关键词：

D O I：

10.1016/0742-8413(85)90225-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Octopamine (OA) hyperpolarizes leech Leydig neurones but response amplitudes and thresholds vary. 2. Associations between response, OA dose and other variables [initial resting potential, action potential (AP) frequency and amplitude, temperature, microelectrode resistance, position of ganglion along nerve cord, animal, treatment order] were examined using canonical correlation. 3. A complex response was expressed by summing changes in membrane potential and AP frequency over 2 min of OA tretment. 4. Only dose and ganglion position influenced this response. One significant canonical variate related dose to immediate changes in membrane potential and summed changes in AP frequency throughout the OA effect. Response to OA was greater in cells in posterior ganglia.

引用

页码：165 / 170

页数：6

共 29 条

[1]

[Anonymous], 1947, J R STAT SOC S, DOI DOI 10.2307/2984113

[2]

Chatfield C., 1980, Introd Multivar Anal, V1, P162

[3]

DEAN J A, 1984, British Journal of Pharmacology, V81, p126P

[4]

DIXON WJ, 1979, BIOMEDICAL COMPUTE P

[5] ACTION OF OCTOPAMINE AGONISTS AND STEREO ISOMERS AT A SPECIFIC OCTOPAMINE RECEPTOR [J].

DOUGAN, DFH ;

WADE, DN .

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1978, 5 (04) :333-339

[6]

EVANS PD, 1981, J PHYSIOL-LONDON, V318, P99

[7] OCTOPAMINERGIC NEURON MODULATES NEUROMUSCULAR-TRANSMISSION IN LOCUST [J].

EVANS, PD ;

OSHEA, M .

NATURE, 1977, 270 (5634) :257-259

[8] OCTOPAMINE NEURONS - MORPHOLOGY, RELEASE OF OCTOPAMINE AND POSSIBLE PHYSIOLOGICAL-ROLE [J].

EVANS, PD ;

TALAMO, BR ;

KRAVITZ, EA .

BRAIN RESEARCH, 1975, 90 (02) :340-347

[9] OCTOPAMINE RELEASE AT 2 POINTS ALONG LOBSTER NERVE TRUNKS [J].

EVANS, PD ;

KRAVITZ, EA ;

TALAMO, BR .

JOURNAL OF PHYSIOLOGY-LONDON, 1976, 262 (01) :71-&

[10] EFFECTS OF OCTOPAMINE AND OTHER AMINES ON HEART AND ON NEUROMUSCULAR-TRANSMISSION IN DECAPOD CRUSTACEANS - FURTHER EVIDENCE FOR A ROLE AS NEUROHORMONE [J].

FLOREY, E ;

RATHMAYER, M .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY, 1978, 61 (01) :229-237

← 1 2 3 →