HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ELECTROCHEMICAL DETECTION OF VECURONIUM AND ITS METABOLITES IN HUMAN PLASMA

被引：25

作者：

DUCHARME, J

VARIN, F

BEVAN, DR

DONATI, F

THEORET, Y

机构：

[1] UNIV MONTREAL,FAC PHARM,2900 EDOUARD MONTPETIT,SUCC A,CP 6128,MONTREAL H3C 3J7,QUEBEC,CANADA

[2] MCGILL UNIV,DEPT ANAESTHESIA,MONTREAL H3A 1A1,QUEBEC,CANADA

[3] UNIV MONTREAL,DEPT PHARMACOL,MONTREAL H3C 3J7,QUEBEC,CANADA

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1992年 / 573卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0378-4347(92)80477-8

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A high-performance liquid chromatographic assay coupled with electrochemical detection has been developed for the determination of vecuronium and its three putative deacetylated metabolites in human plasma. A novel solid-phase extraction procedure allowed good recovery of both vecuronium and its metabolites, together with ease and speed of execution. This method was sensitive, reproducible and accurate over the therapeutic range of concentrations of vecuronium and its metabolites, and was applied successfully to a study of the pharmacokinetics of vecuronium in anaesthetized patients.

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收藏

页码：79 / 86

页数：8

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