SYNTHESIS OF OPTICALLY PURE FLUORO-CYCLOHEXANE AND GEM-CHLOROFLUORO-CYCLOHEXANE DERIVATIVES BY INTRAMOLECULAR TRAPPING OF DIHALOALKYL RADICALS

被引：7

作者：

ARNONE, A ^{[1
]}

BRAVO, P ^{[1
]}

CAVICCHIO, G ^{[1
]}

FRIGERIO, M ^{[1
]}

VIANI, F ^{[1
]}

机构：

[1] CNR,CTR STUDIO SOSTANZE ORGAN NAT,POLITECN,DIPARTIMENTO CHIM,I-20133 MILAN,ITALY

来源：

TETRAHEDRON-ASYMMETRY | 1992年 / 3卷 / 01期

关键词：

ASYMMETRIC SYNTHESIS; FLUOROCYCLOHEXANOLS; CHLOROFLUOROCYCLOHEXANOLS; CHLOROFLUOROALKYL RADICALS;

D O I：

10.1016/S0957-4166(00)82303-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

gem-Chlorofluorocyclohexanols 8 bearing a methyl and a p-tolylsulphinyl substituent have been obtained in optically pure form by radical cyclization of the corresponding halo-alkenes 4. Reductive dechlorination of both (6R)- and (6S)-8 gave fluoroderivative (6R)-9, which through functional group elaborations gave the hydroxyfluoro- and trihydroxyfluoro-cyclohexane derivatives 12 and 15.

引用

页码：9 / 12

页数：4

共 34 条

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