MALARIA VACCINES - PROGRESS AND PROBLEMS

被引:17
作者
COX, FEG
机构
[1] F. E. G. Cox is at the Division of Biomolecular Sciences, King's College London, London, W8 7AH, Campden Hill Road
关键词
D O I
10.1016/0167-7799(91)90131-Z
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Developing a vaccine against malaria is a major priority of the WHO. A decade of research exploiting the techniques of molecular biology has yielded a series of potentially protective vaccines. However, progress has been frustrated by the complexity of the parasite's life cycle and the antigenic diversity exhibited by each stage. Although candidate vaccines are now entering human trials, questions still arise concerning the nature of a successful malaria vaccine and who will benefit from it.
引用
收藏
页码:389 / 393
页数:5
相关论文
共 43 条
[1]  
Anders R.F., 1989, P19
[2]  
BALLOU WR, 1987, LANCET, V1, P1277
[3]  
CARRIER MJ, 1989, VACCINATION STRATEGI, P11
[4]  
Clark I. A., 1989, Malaria: host responses to infection., P127
[5]   PROPOSED LINK BETWEEN CYTOKINES, NITRIC-OXIDE AND HUMAN CEREBRAL MALARIA [J].
CLARK, IA ;
ROCKETT, KA ;
COWDEN, WB .
PARASITOLOGY TODAY, 1991, 7 (08) :205-207
[6]  
CLYDE DF, 1990, B WORLD HEALTH ORGAN, V68, P9
[7]   IMMUNIZATION OF AOTUS MONKEYS WITH RECOMBINANT PROTEINS OF AN ERYTHROCYTE SURFACE-ANTIGEN OF PLASMODIUM-FALCIPARUM [J].
COLLINS, WE ;
ANDERS, RF ;
PAPPAIOANOU, M ;
CAMPBELL, GH ;
BROWN, GV ;
KEMP, DJ ;
COPPEL, RL ;
SKINNER, JC ;
ANDRYSIAK, PM ;
FAVALORO, JM ;
CORCORAN, LM ;
BRODERSON, JR ;
MITCHELL, GF ;
CAMPBELL, CC .
NATURE, 1986, 323 (6085) :259-262
[8]  
Cruz V. F. de la, 1988, Technological Advances in Vaccine Development (Proceedings of a Genentech, Ortho, Smith Kline & French-UCLA Symposium, 30 Jan.-6 Feb. 1988, Park City, Utah, USA)., P615
[9]  
DOUGAN G, 1989, VACCINATION STRATEGI, P47
[10]   STRUCTURAL AND ANTIGENIC POLYMORPHISM OF THE 35-KILODALTON TO 48-KILODALTON MEROZOITE SURFACE-ANTIGEN (MSA-2) OF THE MALARIA PARASITE PLASMODIUM-FALCIPARUM [J].
FENTON, B ;
CLARK, JT ;
KHAN, CMA ;
ROBINSON, JV ;
WALLIKER, D ;
RIDLEY, R ;
SCAIFE, JG ;
MCBRIDE, JS .
MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (02) :963-971