ASYMMETRIC DEPROTONATION AS AN EFFICIENT ENANTIOSELECTIVE PREPARATION OF FUNCTIONALIZED SECONDARY ALCOHOLS

被引：22

作者：

KNOCHEL, P

机构：

[1] Fachbereich Chemie, Philipps‐Universität, Marburg, D-W-3550, Hans‐Meerwein‐Strasse

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1992年 / 31卷 / 11期

关键词：

D O I：

10.1002/anie.199214591

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A reaction with organolithium compounds and the chiral amine (-)-sparteine deprotonates carbamates such as 1 in the alpha-position forming chiral lithio compounds 2, as shown by D. Hoppe et al. [Eq. (a)]. These react with high stereoselectivity with a variety of electrophiles to yield nonracemic, chiral compounds (see also the communication on p. 1505 ff). R1 = alkenyl, R2 = C(O)NiPr2, R3 = nBuLi.

引用

页码：1459 / 1461

页数：3

共 38 条

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