CALCIUM, CALMODULIN AND CELL-CYCLE REGULATION

被引:248
作者
MEANS, AR
机构
关键词
CALCIUM; CALMODULIN; CELL CYCLE; PROTEIN KINASE; PROTEIN PHOSPHATASE;
D O I
10.1016/0014-5793(94)00492-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Calcium and its ubiquitous intracellular receptor calmodulin are required for cell proliferation. Studies in a variety of model systems are beginning to identify components of the calcium/calmodulin cascade required for movement of quiescent cells into the cell cycle as well as for proliferating cells to move from G, to S, G, to M and through mitosis. Two calcium/calmodulin-dependent enzymes, the multifunctional calcium/calmodulin-dependent protein kinase and the protein phosphatase 2B (calcineurin) as well as a spindle pole body protein that binds calmodulin in the absence of calcium have been shown to be essential at specific phases of the cell cycle. In addition, the status of the intracellular calcium pools is critical for normal traverse of the cell cycle.
引用
收藏
页码:1 / 4
页数:4
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